Functional connectivity is altered by APOE4 carrier status in cognitively healthy older adults

Abstract Background Resting‐state connectivity allows for investigating brain network changes in pathologic states of aging, such as Alzheimer’s Disease (AD). Recently, have been associated with AD‐related risk factors asymptomatic individuals. We explored how is affected by one factor, apolipoprotein e4 ( APOE4) carrier status. Methods In a sample cognitively healthy older adults (n=102), we acquired demographic information, APOE4 status, and resting‐state fMRI scans. Individuals were designated “ carrier” the presence at least allele. No APOE2 carriers included analyses. Using independent component analysis approaches both individual de‐noising group‐level analysis, identified key networks traditionally decline. Utilizing nonparametric permutation inference, tested differences to these based on Results multiple altered functional across groups, including One region, anterior cingulate cortex, showed resting state networks. Functional was decreased compared non‐carriers. Conclusion highlight dependent upon genetic risk. Our results add growing body evidence that along other AD, alter large‐scale Additional characterization interaction status biomarkers warranted.